The use of new antigens in the complementfixation test for acute poliomyelitis.

نویسنده

  • G SELZER
چکیده

Hitherto in poliomyelitis complement-fixation tests on human sera the antigenic material has usually been derived from tissue cultures of polio viruses. Despite high infectivity titres, antigens from this source are weak in capacity to fix complement (Selzer, 1958). Concentration of tissue culture antigens improves the complement-fixing power but frequently produces anti-complementary effects. Heating the antigens abolishes the anti-complementary state but often results in loss of homotypic specificity (Le Bouvier, 1955; Schmidt & Lennette, 1956). When polioviruses Types 1 and 2 were successfully adapted to suckling mice in this laboratory the possibility of improving the complement-fixation test by the use of antigenic extracts from infected suckling mouse brain was envisaged. This publication records the results of investigations of these new antigens.

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عنوان ژورنال:
  • The Journal of hygiene

دوره 58  شماره 

صفحات  -

تاریخ انتشار 1960